Spybot - Search & Destroy has detected a change to a System Startup entry.

Spybot-S&D Resident watches for changes to this setting, and allows you to react to them.

Not all startup entries are bad - you have to decide if you trust the program that asks the change. During a user-initiated software installation for example, you would usually allow this change. If this happens while surfing the web or without any intended system changes, you should be careful.